Thursday, October 10, 2013

Legally dead

Once you have been declared dead, it may be difficult to be declared alive again, at least if you live in Ohio and were declared dead more than three years ago:
Donald Miller Jr. went to court this week to ask a county judge to reverse a 1994 ruling that declared him legally dead after he had vanished from his home eight years earlier. But the judge turned down his request, citing a three-year time limit for changing a death ruling.
No medical opinion required!

Read more: US Judge Tells Man He's Still Legally Dead

Friday, June 22, 2012

Spearing the Brain

Well, I've been slow to update this blog, and meaning to post this story since I came across it: Docs Reveal Stunning Images Of Teen With Spear Through Head In brief: Doctors remove a spear (accidentally deployed from a speargun in what the story calls a "freak accident") that entered just above a teenage boy's right eye, and then penetrated the back of his skull. The pictures are amazing, as is the boy's expected recovery.

Tuesday, April 10, 2012

Trepanation kit

Just came across a lovely trepanation kit, featured on BoingBoing. David Pescovitz writes:
Over the years, I've spotted many trephination tools at various antique scientifica dealers. But this complete set is by far the most stately I've ever seen. No wonder it's in London's Wellcome Collection on display as part of their current Brains exhibition.
To see a picture of the kit and read more about it, see Skull drill set from the 18th century.

Monday, March 12, 2012

Love and the Brain

Last night, I watched a fabulous short film called "The Love Competition" by Brett Hoff. I saw it on Wholphin (which I subscribe to and love), but the piece can be viewed *right now* on Vimeo: http://vimeo.com/33698394, and I recommend you check it out asap.

The premise? A team of Stanford neuroscientists scans the brains of a half-dozen or so competitors (aged 10-75) as they love as hard as they can for five minutes. MRI scans reveal the winners! The brain reveals all, perhaps.

Tuesday, February 21, 2012

Is that your brainwaves talking?

The brain may not be able to speak quite yet, but researchers at the University of California, Berkeley are working to correlate speech to the brain's neural activity.
Using algorithms to interpret the neural activity, they created a graphical representation of the data, which they later converted back to audible speech.
"People listening to the audio replays may be able to pull out coarse similarities between the real word and the constructed words," says Pasley. When New Scientist listened to the words, they could just about make out "Waldo" and "structure". However, its fidelity was sufficient for the team to identify individual words using computer analysis.

Is reading minds just around the bend? Not likely, but researchers hope to help people like Erik Ramsey, who is paralysed.

To read the full story, see Telepathy machine reconstructs speech from brainwaves by Helen Thomson

Tuesday, January 24, 2012

Old Brains and Mental Illness

Just came across this very interesting piece by Virginia Hughes in Scientific American about the Indiana Medical History Museum, formerly the pathology department of the Central Indiana Hospital for the Insane, and now back in the news because of a frustrating "dearth of postmortem brain donations from people with mental illness." The solution? Mining genetic information from "old, often forgotten tissue archives".

Though studying old brains is not without challenges, the tissue is free from modern psychiatric drugs, and is, in the words of John Allman, a professor of biology at the California Institute of Technology, "an untapped resource."

To read the entire story, see Shelf-Preservation: Researchers Tap Century-Old Brain Tissue for Clues to Mental Illness

Wednesday, December 7, 2011

If someone slipped you valium...

This week's New Yorker contains an article by Michael Specter that I was compelled to read at once. The topic? Placebos. In this fascinating piece, Specter offers important details such as:
In most cases, the larger the pill, the stronger the plecebo effect. Two pills are better than one, and brand-name pills trump generics. Capsules are generally more effective than pills, and injections produce a more pronounced effect than either.
And:
Thomas Jefferson... noted that 'one of the most successful physicians I have ever known has assured me that he used more bread pills, drops of coloured water, and powders of hickory ashes, than of all other medicines put together.'
And, perhaps my favorite, that doctors have found:
...that diazepam--more commonly known as Valium--has no discernible effect on anxiety unless a person knows he is taking it.
To read the article, see The Power of Nothing.

Monday, October 31, 2011

This is your brain on ayahuasca. Or is it?

Reporting for New Scientist, Arran Frood brings us the results of a Brazilian study that looked at the brain activity of frequent users of ayahuasca, a tea prepared from a jungle vine and traditionally used by shamans. Researchers scanned the brains of subjects as they looked at images of people or animals, as they closed their eyes and imagined the object, and as they closed their eyes and imagined the objects after a dose of ayahuasca. The results?
...researchers found that neural activity in the primary visual cortex dropped off when volunteers imagined seeing the image rather than actually viewing it.

But when the team then gave the volunteers a dose of ayahuasca and repeated the experiment, they found that the level of activity in the primary visual cortex was virtually indistinguishable when the volunteers were really viewing an image and when they were imagining it. This means visions seen have a real, neurological basis, says de Araujo – they are not made up or imagined.

Evidently, the pharmacology of ayahuasca resembles that of some more conventional drugs for treating addiction, depression, and post-traumatic stress disorder. Perhaps this Amazon concoction will join the ranks of LSD in tomorrow's medicine cabinet.
To read the entire story, see Drug hallucinations look real in the brain

Monday, September 12, 2011

The Brain on Magnets

Sure, we all know about lie-detector tests. But wouldn't it be easier to simply make sure no one lies to begin with? Talis Bachmann's team at the University of Tartu in Estoni thinks this might be possible. After applying transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC)--which is involved in cognitive control--the team found that patients were more likely to be truthful.

Is it true? Judge for yourself: to read more see Powerful magnets hamper our ability to lie.

Monday, August 29, 2011

Hollywood on the brain

Chris Colin brings us the story of Simon Lewis, a successful film producer who lost a "full third of his right hemisphere" after a terrifying car accident. Lewis fell into a deep coma, only to defy the odds against him by emerging from it a month later:
He would move into his parent' house that summer, 1994, but that was just the beginning of a seemingly endless medical journey. No sooner would he recuperate from one grueling surgery than he'd be back for another. The months turned to years. His recovery lasted a decade and a half.
And now? Lewis says he wants to make films again, incorporating some of the new ways he perceives the world (particularly "flat time" and "blind sight," which Colin describes in detail in his book) into his art. "He wanted to make different movies because he had a different brain inside his skull and a different way of experiencing the world," Colin writes. In Lewis' words:
Picture all the memories from your life as a photo album. Then take out all the photos and shuffle them across a table. That's my brain... It can be frustrating, but as far as making interesting connections goes, it certainly opens things up in a new way.
Will his movies be made? Only time will tell. But the story is an amazing one. To read an excerpt of the story in the Atlantic, see The Hollywood Producer Who Survived Catastrophe or buy the ebook (just 1.99) at Amazon.

Friday, August 19, 2011

The Queen is Dead: The Story of an Ancient Medicinal Tonic

After two years studying the dessicated contents of Queen Hathshepsut's beauty cream, a team of researchers at the University of Bonn have concluded that a carcinogenic substance in the flask may have poisoned her.

The queen, who was evidently obese and suffered from diabetes and liver cancer as well as eczema, ruled Egypt 3,500 years ago. The cream contained palm and nutmeg oil and fatty acids that relieve skin irritations, as well as benzopyrene, a highly carcinogenic hydrocarbon.

For the full story, as well as a grizzly photograph of the queen herself, see Queen Hatshepsut, Ancient Egyptian Leader, Might Have Accidentally Poisoned Herself: Experts.

Thursday, August 18, 2011

Good old-fashioned trepanation!

Bruce Bower over at Science News reports that a new study conducted by anthropologist Efthymia Nikita of the University of Cambridge in England has found that men were drilling pieces out of each other's skulls to treat wounds or cure other ailments. Over two-thousand years ago!

Nikita, who studied three skulls that once belonged to living men who resided in what is now southwest Libya, determined that the "dime- to quarter-sized holes inside hollowed-out areas, as well as scraped-out depressions" were not from "disease, bone-chewing animals, accidental falls or intentional blows." They are, instead, evidence of surgical procedures performed thousands of years ago.

I wonder if any female skulls have the same pattern of holes and depressions, or if trepanation was just something the boys did back then.

To read the entire article, see: Ancient Saharan head cases

Thursday, August 4, 2011

Spontanteous Human Combustion: It's Ablaze!

Do spontaneous human combustion events happen along some kind of geographical line? Has there been and will there be a "boom" in spontaneous human combustion cases? What is it like to combust spontaneously? These are just a few of the questions Larry E. Arnold, oft called the world's "foremost authority on the phenomenon" and author of Ablaze: The Mysterious Fires of Spontaneous Human Combustion addresses in this two and a half hour interview available here. In addition, his book promises "hundreds of unbelievable examples of The Fire Within, culled from long-forgotten obscure medical journals and never-before-published interviews with witnesses to the impossible." Sounds great!

Thursday, July 21, 2011

The Art of the Brain

Ian Chant recently blogged about a "Brain-Art Competition," designed to help "recognize the beauty and creativity of artistic renderings emerging from the neuroimaging community."

Contest categories included: Best 3-Dimensional Brain Rendering, Best Representation of the Human Connectome, Best Abstract Brain Illustration, and Best Humorous Brain Illustration.

Some great images in here. Enjoy!

Monday, July 18, 2011

Urine makes a comeback!

In the 1650s, it wasn't unheard of for doctors to diagnose disease based on observations of a patient's urine. What, exactly, were those doctors observing using the tools of the times? I'm not sure. However, recent research indicates that urine might be a better indicator than blood (today's standard) to diagnose diseases such as cancers and neurodegenerative disorders.

Using high-resolution Fourier transform mass spectrometry on urine samples collected from healthy subjects, researchers detected 1823 proteins (671 of which had never been previously reported in urine. Ninety percent of these were identified for the first time).

Akhilesh Pandey, who led the research team, says:
We have been able to identify some novel proteins which have implications in important diseases...These proteins are cathepsin L2 (CTSL2) linked to chronic kidney disease, sialyltransferase 1 (ST6GAL1) for acute childhood leukemia, insulin like growth factor binding protein 4 (IGFBP4) for prostate,ovarian and gastrointestinal cancers, mucin-like 1(MUCL1) for breast cancer, and neurocan (NCAN) for bipolar disorder.

To read the complete story, see Urine holds clue to deadly cancers.

Thursday, June 30, 2011

The latest in medicinal tonics

Do you suffer from chronic pain? panic attacks? crippling anxiety? Anneli Rufus reports that a cure may be on the way: Prescription LSD!
Leading this wave is the Boston-based Multidisciplinary Association for Psychedelic Studies (MAPS)... MAPS researchers have spent 15 years conducting international clinical trials whose results indicate that LSD and psilocybin counteract depression and anxiety and are effective pain-management tools while MDMA (ecstasy) conquers fear. Just this month, the Israeli Ministry of Health approved a new MAPS study using MDMA to treat PTSD.
Note that scientists are not saying that you can "recover by hitting a few raves." The drugs should instead be administered by professionals in "a safe, supportive, controlled setting."
To read the full story, see Why Prescription Ecstasy or LSD Could Happen Much Sooner Than You Think

Wednesday, June 29, 2011

Art and Brain Trauma?

Reporting for the New York Times, Dr. Abigail Zuger tells the story of Jon Sarkin, a chiropractor in Massachusetts who was plagued by a "high-pitched screech" that doctors shrugged off as "a vague abonormality near a nerve at the base of the brain that controls hearing and balance."

Maddened by the ceaseless racket, Dr. Sarkin underwent surgery to correct the problem, only to wind up in a coma. The man who emerged from the coma bore little resemblance to the man who fell into it several months before.
He was physically delicate and walked with a cane, but that was the least of it. His personality had morphed into a difficult teenager's: self-centered, unreliable, obsessive.
He also began to draw. Now, twenty years later, he has become "a full-fledged artist of some renown" and has sold work to The New York Times Magazine as well a private collectors. What started as a shriek heard only by himself, became unexpectedly transformative.


Read more here.

Friday, May 20, 2011

Alive or dead? And the brain, of course

A person is either alive, or dead, or... in a "middling state," which can be hard to decipher. According to Amber Dance's article for Nature, "Even when a team of doctors agree to diagnose a vegetative state, they have been shown to be wrong more than 40% of the time compared to the a standardized test, the Coma Recovery Scale."

In other words, when the going gets tough, we're not very good at determining whether someone is with us or not.

However, a new test, developed by Melanie Boly and her team at the University of Liège in Belgium, uses an electroencephalogram (EEG), to peer in at the brain, and the results suggest "that the key difference between minimally conscious and totally unconscious non-coma states is communication between the frontal cortex — the planning, thinking part of the brain — and the temporal cortex, where sounds and words are processed."

Here's more:
Boly and her colleagues...used EEG to measure electrical signals from the brains of 8 people in vegetative states, 13 in minimally conscious states and 22 healthy participants. The subjects were played a series of tones, which occasionally changed in pitch. The differing tone constituted a surprising event in the environment — something that the frontal cortex has to consider, so in all subjects the temporal cortex would send the frontal cortex a message.

In minimally conscious and healthy people the frontal cortex would then send a message back to the temporal cortex. The reason for this is uncertain; it may be to let the temporal cortex know what to expect in the future. But for people in a vegetative state, the communication was one-way: signals passed from the temporal to frontal area, but not back.

Interesting stuff. To read even more, see Test measures spark of consciousness

Tuesday, May 17, 2011

Grey matter turns blue!

Boing Boing recently brought us news of the Blue Brain Project, which is, according to its website:
Reconstructing the brain piece by piece and building a virtual brain in a supercomputer—these are some of the goals of the Blue Brain Project. The virtual brain will be an exceptional tool giving neuroscientists a new understanding of the brain and a better understanding of neurological diseases.
The team has already successfully simulated a rat cortical column (evidently, there are about 100,000 such columns in the average rat brain). The human brain has more like two million (even more complex) columns.

Constructing a model of the human brain will require a fair amount of computing power:
Each simulated neuron requires the equivalent of a laptop computer. A model of the whole brain would have billions.

The technology of medicine marches forward!

For photos of the team and project, see Blue Brain Project: Build a virtual brain in a supercomputer.

Friday, May 13, 2011

It's all about the marketing

The Scientist has a great story about William Helfand's medical poster collection, which contains thousands of marketing posters and other assorted "marketing paraphernalia" dating back to the 1920s. The article features a poster for Uricure, which depicts a rather deranged looking bearded man holding aloft a small box of the substance. The article explains:
Uricure was a drug purported to improve rheumatism, arthritis, gout, and kidney disorders. The molecular details of the product are unknown, however, as is its therapeutic value.
The posters in the slide show are even more amazing, featuring slogans like, "Weed with roots in hell" and skeletons pouring cups of allegedly curative tonics.

To read the entire article, see Edyta Zielinska's, Medical Posters, circa 1920.