The Art of the Brain

Ian Chant recently blogged about a "Brain-Art Competition," designed to help "recognize the beauty and creativity of artistic renderings emerging from the neuroimaging community."

Contest categories included: Best 3-Dimensional Brain Rendering, Best Representation of the Human Connectome, Best Abstract Brain Illustration, and Best Humorous Brain Illustration.

Some great images in here. Enjoy!

Urine makes a comeback!

In the 1650s, it wasn't unheard of for doctors to diagnose disease based on observations of a patient's urine. What, exactly, were those doctors observing using the tools of the times? I'm not sure. However, recent research indicates that urine might be a better indicator than blood (today's standard) to diagnose diseases such as cancers and neurodegenerative disorders.

Using high-resolution Fourier transform mass spectrometry on urine samples collected from healthy subjects, researchers detected 1823 proteins (671 of which had never been previously reported in urine. Ninety percent of these were identified for the first time).

Akhilesh Pandey, who led the research team, says:

We have been able to identify some novel proteins which have implications in important diseases...These proteins are cathepsin L2 (CTSL2) linked to chronic kidney disease, sialyltransferase 1 (ST6GAL1) for acute childhood leukemia, insulin like growth factor binding protein 4 (IGFBP4) for prostate,ovarian and gastrointestinal cancers, mucin-like 1(MUCL1) for breast cancer, and neurocan (NCAN) for bipolar disorder.

To read the complete story, see Urine holds clue to deadly cancers.

The latest in medicinal tonics

Do you suffer from chronic pain? panic attacks? crippling anxiety? Anneli Rufus reports that a cure may be on the way: Prescription LSD!

Leading this wave is the Boston-based Multidisciplinary Association for Psychedelic Studies (MAPS)... MAPS researchers have spent 15 years conducting international clinical trials whose results indicate that LSD and psilocybin counteract depression and anxiety and are effective pain-management tools while MDMA (ecstasy) conquers fear. Just this month, the Israeli Ministry of Health approved a new MAPS study using MDMA to treat PTSD.

Note that scientists are not saying that you can "recover by hitting a few raves." The drugs should instead be administered by professionals in "a safe, supportive, controlled setting."
To read the full story, see Why Prescription Ecstasy or LSD Could Happen Much Sooner Than You Think

Art and Brain Trauma?

Reporting for the New York Times, Dr. Abigail Zuger tells the story of Jon Sarkin, a chiropractor in Massachusetts who was plagued by a "high-pitched screech" that doctors shrugged off as "a vague abonormality near a nerve at the base of the brain that controls hearing and balance."

Maddened by the ceaseless racket, Dr. Sarkin underwent surgery to correct the problem, only to wind up in a coma. The man who emerged from the coma bore little resemblance to the man who fell into it several months before.

He was physically delicate and walked with a cane, but that was the least of it. His personality had morphed into a difficult teenager's: self-centered, unreliable, obsessive.

He also began to draw. Now, twenty years later, he has become "a full-fledged artist of some renown" and has sold work to The New York Times Magazine as well a private collectors. What started as a shriek heard only by himself, became unexpectedly transformative.


Read more here.

Alive or dead? And the brain, of course

A person is either alive, or dead, or... in a "middling state," which can be hard to decipher. According to Amber Dance's article for Nature, "Even when a team of doctors agree to diagnose a vegetative state, they have been shown to be wrong more than 40% of the time compared to the a standardized test, the Coma Recovery Scale."

In other words, when the going gets tough, we're not very good at determining whether someone is with us or not.

However, a new test, developed by Melanie Boly and her team at the University of Liège in Belgium, uses an electroencephalogram (EEG), to peer in at the brain, and the results suggest "that the key difference between minimally conscious and totally unconscious non-coma states is communication between the frontal cortex — the planning, thinking part of the brain — and the temporal cortex, where sounds and words are processed."

Here's more:

Boly and her colleagues...used EEG to measure electrical signals from the brains of 8 people in vegetative states, 13 in minimally conscious states and 22 healthy participants. The subjects were played a series of tones, which occasionally changed in pitch. The differing tone constituted a surprising event in the environment — something that the frontal cortex has to consider, so in all subjects the temporal cortex would send the frontal cortex a message.

In minimally conscious and healthy people the frontal cortex would then send a message back to the temporal cortex. The reason for this is uncertain; it may be to let the temporal cortex know what to expect in the future. But for people in a vegetative state, the communication was one-way: signals passed from the temporal to frontal area, but not back.

Interesting stuff. To read even more, see Test measures spark of consciousness

Grey matter turns blue!

Boing Boing recently brought us news of the Blue Brain Project, which is, according to its website:

Reconstructing the brain piece by piece and building a virtual brain in a supercomputer—these are some of the goals of the Blue Brain Project. The virtual brain will be an exceptional tool giving neuroscientists a new understanding of the brain and a better understanding of neurological diseases.

The team has already successfully simulated a rat cortical column (evidently, there are about 100,000 such columns in the average rat brain). The human brain has more like two million (even more complex) columns.

Constructing a model of the human brain will require a fair amount of computing power:

Each simulated neuron requires the equivalent of a laptop computer. A model of the whole brain would have billions.

The technology of medicine marches forward!

For photos of the team and project, see Blue Brain Project: Build a virtual brain in a supercomputer.

It's all about the marketing

The Scientist has a great story about William Helfand's medical poster collection, which contains thousands of marketing posters and other assorted "marketing paraphernalia" dating back to the 1920s. The article features a poster for Uricure, which depicts a rather deranged looking bearded man holding aloft a small box of the substance. The article explains:

Uricure was a drug purported to improve rheumatism, arthritis, gout, and kidney disorders. The molecular details of the product are unknown, however, as is its therapeutic value.

The posters in the slide show are even more amazing, featuring slogans like, "Weed with roots in hell" and skeletons pouring cups of allegedly curative tonics.

To read the entire article, see Edyta Zielinska's, Medical Posters, circa 1920.